HyperClick II 2.1.0
HyperClick II lets you create keyboard and mouse shortcuts and combos, so you can click 50 times/ sec, or fire off a combination of keys with a single button.
Fully configurable, so you can create any combo you want then activate it with the combo's hotkey, or keep firing off the combo for as long as you hold the key down. You can even create a set of shortcuts for each game or application.
Tested on (and tweaked for) a wide variety of game types: real-time-strategy, moderate-sized single-player RPGs, first-person shooters, and even the occasional hidden-picture or room-escape game (for when you just aren't sure where to click, and are tired of trying to figure it out...)
Not necessarily designed for line-of-business applications, so we actually have no idea if it'll help with real work...
Enjoy, and have fun!