SuperDuper is the wildly acclaimed program that makes recovery painless, because it makes creating a fully bootable backup painless.
Its incredibly clear, friendly interface is understandable, easy to use, and SuperDuper's built-in scheduler makes it trivial to back up automatically. It's the perfect complement to Time Machine under Leopard, allowing you to store a bootable backup alongside your Time Machine volume—and it runs beautifully on both Intel and Power PC Macs!
Paid version allows for scheduled back ups and scripting, too.
Mac OS X 10.4 or higher.